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Short-term effect of temperature variation on the competition between PAOs and GAOs during acclimation period of an EBPR system

Nanqi REN, Han KANG, Xiuheng WANG, Nan LI

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 2,   Pages 277-282 doi: 10.1007/s11783-010-0226-x

Abstract: PAOs and GAOs were analyzed by fluorescent in situ hybridization (FISH), and intracellular polyphosphateWith the evidence of poly-P granules containing by Neisser-straining and result of FISH, these organisms

Keywords： fluorescent in situ hybridization (FISH)     tetrad forming organisms (TFOs)     temperature variation     enhanced    

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Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy in NSCLC

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 493-502 doi: 10.1007/s11684-022-0946-x

Abstract: Anaplastic lymphoma kinase (ALK) is the most common fusion gene involved in non-small cell lung cancer (NSCLC), and remarkable response has been achieved with the use of ALK tyrosine kinase inhibitors (ALK-TKIs). However, the clinical efficacy is highly variable. Pre-existing intratumoral heterogeneity (ITH) has been proven to contribute to the poor treatment response and the resistance to targeted therapies. In this work, we investigated whether the variant allele frequencies (VAFs) of ALK fusions can help assess ITH and predict targeted therapy efficacy. Through the application of next-generation sequencing (NGS), 7.2% (326/4548) of patients were detected to be ALK positive. On the basis of the adjusted VAF (adjVAF, VAF normalization for tumor purity) of four different threshold values (adjVAF < 50%, 40%, 30%, or 20%), the association of ALK subclonality with crizotinib efficacy was assessed. Nonetheless, no statistical association was observed between median progression-free survival (PFS) and ALK subclonality assessed by adjVAF, and a poor correlation of adjVAF with PFS was found among the 85 patients who received first-line crizotinib. Results suggest that the ALK VAF determined by hybrid capture-based NGS is probably unreliable for ITH assessment and targeted therapy efficacy prediction in NSCLC.

Keywords： ALK fusion     next-generation sequencing     fluorescence in situ hybridization     immunohistochemistry    

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Determination and occurrence of endocrine disrupting compounds, pharmaceuticals and personal care products in fish

Yong YU,Laosheng WU

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 3,   Pages 475-481 doi: 10.1007/s11783-014-0640-6

Abstract: In this study, we determined 13 EDCs and PPCPs in fish blood, bile and muscle by using gas chromatography-massquantitation (LOQ) were in the ranges of 0.23–2.54, 0.22–2.36 ng·mL , and 0.24–2.57 ng·g dry weight (dw) for fishThe methods were applied to the analysis of fish from a lake in California.The estimated daily intake of BPA through fish consumption for U.S. resident was significantly lowerThis study showed that the exposure to the bisphenol A from fish diet is unlikely to pose a health risk

Keywords： endocrine disrupting compounds (EDCs)     pharmaceuticals and personal care products (PPCPs)     fish     bisphenol    

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Information gathering and processing with fluorescent molecules

Brian DALY,Jue LING,A. Prasanna de SILVA

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2,   Pages 240-251 doi: 10.1007/s11705-014-1432-z

Abstract: Molecular information gathering and processing — a young field of applied chemistry — is undergoing good growth. The progress is occurring both in terms of conceptual development and in terms of the strengthening of older concepts with new examples. This review critically surveys these two broad avenues. We consider some cases where molecules emulate one of the building blocks of electronic logic gates. We then examine molecular emulation of various Boolean logic gates carrying one, two or three inputs. Some single-input gates are popular information gathering devices. Special systems, such as ‘lab-on-a-molecule’ and molecular keypad locks, also receive attention. A situation deviating from the Boolean blueprint is also discussed. Some pointers are offered for maintaining the upward curve of the field.

Keywords： molecular logic     molecular computation     molecular sensor     fluorescent molecular device     fluorescent sensor    

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Differentiation of Phenol-Degrading Microorganisms in UASB Granular Sludge as Revealed by Fluorescence in situ Hybridization Article

Kengo Kubota, Kei Igarashi, Masayoshi Yamada, Yasuyuki Takemura, Yu-You Li, Hideki Harada

Engineering 2022, Volume 9, Issue 2,   Pages 61-66 doi: 10.1016/j.eng.2021.05.012

Abstract: anaerobic sludge blanket reactor treating phenolic wastewater was investigated using fluorescence in situhybridization (FISH) and clone library construction.FISH analysis of thin sections of anaerobic granules showed a random distribution of Bacteria and Archaea

Keywords： Cryptanaerobacter     Fluorescence     in situ     hybridization     Anaerobic phenol degradation     Syntrophorhabdaceae    

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The Sustainable Exploitation of Marine Fish Resources and the Research Directions of Science and Technologyfor Marine Fish

Lin Haoran

Strategic Study of CAE 2003, Volume 5, Issue 3,   Pages 27-30

Abstract: fundamental measure and effective avenue for the reasonable and sustainable exploitation of marine fishimmunology and the molecular biology are the theoretical basis of the proliferation and culture in marine fishnowadays has become the frontier and major research direction of the science and technology for marine fish

Keywords： marine fish resource     sustainable exploitation proliferation and culture of marine fish     science and technologyfor marine fish     marine biotechnology    

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Recent advances of small-molecule fluorescent probes for detecting biological hydrogen sulfide

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 34-63 doi: 10.1007/s11705-021-2050-1

Abstract: has realized the study of H2S in subcellular organelles, facilitated by the development of fluorescent

Keywords： hydrogen sulfide     fluorescent probe     reducibility     nucleophilicity     copper sulfide precipitate     hydrogen    

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Comments on “Determination of heterozygosity for avirulence/virulence loci through sexual hybridization

Ralf T. Voegele

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 1,   Pages 121-122 doi: 10.15302/J-FASE-2017142

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Determination of heterozygosity for avirulence/virulence loci through sexual hybridization of

Yuan TIAN,Gangming ZHAN,Xia LU,Jie ZHAO,Lili HUANG,Zhensheng KANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 1,   Pages 48-58 doi: 10.15302/J-FASE-2016114

Abstract: Wheat stripe rust caused by f. sp. is one of the most devastating diseases of wheat worldwide and resistant cultivars are vital for its management. Therefore, investigating the heterozygosity of the pathogen is important because of rapid virulence changes in isolates heterozygous for avirulence/virulence. An isolate of f. sp. was selfed on to determine the heterozygosity for avirulence/virulence loci. One hundred and twenty progeny isolates obtained from this selfing were phenotyped using 25 lines of wheat containing genes and genotyped with 96 simple sequencing repeat markers, with 51 pathotypes and 55 multi-locus genotypes being identified. All of these were avirulent on lines with , , , and and virulent on lines with , and , indicating that the parental isolate was homozygously avirulent or homozygously virulent for these loci. Segregation was found for wheat lines with , , , , , , , , , , , , , , , and . The 17 cultivars to which the was identified as heterozygous with respect to virulence/avirulence should not be given priority in breeding programs to obtain new resistant cultivars.

Keywords： Puccinia striiformis f. sp. tritici     selfing     heterozygosity     virulence inheritance    

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Short-term effects of excessive anaerobic reaction time on anaerobic metabolism of denitrifying polyphosphate- accumulating organisms linked to phosphorus removal and N

Gang GUO, Yayi WANG, Chong WANG, Hong WANG, Mianli PAN, Shaowei CHEN

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 4,   Pages 616-624 doi: 10.1007/s11783-013-0505-4

Abstract: The fluorescence in situ hybridization (FISH) analysis revealed that the sludge was mainly dominated

Keywords： removal     anaerobic reaction time     nitrous oxide     polyhydroxyalkanoate     free nitrous acid     fluorescence in-situhybridization    

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Fluorescent properties and

Hong GAO,Jie SONG,Shibin SHANG,Zhanqian SONG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 1,   Pages 106-115 doi: 10.15302/J-FASE-2017133

Abstract: series of dehydroabietic acid-based diarylamines have been synthesized in order to investigate their fluorescentmolecular geometry, HOMO and LUMO energies, and energy gaps are important to predict absorption and fluorescentcarcinoma SMMC-7721, human gastric cancer SGC-7901 and human lung adenocarcinoma A549 cells and strong blue fluorescentThese compounds are potential candidates for fluorescent probes in biological diagnosis.

Keywords： dehydroabietic acid-based diarylamine     DFT study     fluorescent probe     in vitro imaging    

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A novel flavonol-based colorimetric and turn-on fluorescent probe for rapid determination of hydrazine

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 1,   Pages 24-33 doi: 10.1007/s11705-022-2171-1

Abstract: Herein, a novel fluorescent probe 4-oxo-2-styryl-4H-chromen-3-yl thiophene-2-carboxylate (FHTstrips were able to conveniently detect hydrazine of low concentration through distinct naked-eye and fluorescent

Keywords： cinnamaldehyde     3-hydroxychromone derivative     hydrazine     fluorescent probe    

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Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 112-120 doi: 10.1007/s11705-021-2075-5

Abstract: both reporting and imaging agents in vitro and in vivo without the need to add other fluorescent

Keywords： fluorescent drug     lysosomal     anticancer     zebrafish     nude-mouse tumour imaging    

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Fluorescent probes and functional materials for biomedical applications

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 10,   Pages 1425-1437 doi: 10.1007/s11705-022-2163-1

Abstract: Due to their simplicity in preparation, sensitivity and selectivity, fluorescent probes have become theIn addition, many long-wavelength fluorescent probes developed have also proven applicable for inHere, we highlight examples of fluorescent probes and functional materials for biological applicationsselected from the special issues “Fluorescent Probes” and “Molecular Sensors and Logic Gates” recently

Keywords： fluorescent probes     imaging     cell     biomedicine     biomolecules    

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Effect of fiber hybridization on energy absorption and synergy in concrete

Ahmadreza RAMEZANI, Mohammad Reza ESFAHANI

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 6,   Pages 1338-1349 doi: 10.1007/s17009-019-0558-2

Abstract: main concentration being on energy absorption characteristics of concrete and the efficacy of fiber hybridization

Keywords： hybrid fiber-reinforced concrete     synergy     toughness     steel fibers     polypropylene fibers    

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Title Author Date Type Operation

Short-term effect of temperature variation on the competition between PAOs and GAOs during acclimation period of an EBPR system

Nanqi REN, Han KANG, Xiuheng WANG, Nan LI

Journal Article

Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy in NSCLC

Journal Article

Determination and occurrence of endocrine disrupting compounds, pharmaceuticals and personal care products in fish

Yong YU,Laosheng WU

Journal Article

Information gathering and processing with fluorescent molecules

Brian DALY,Jue LING,A. Prasanna de SILVA

Journal Article

Differentiation of Phenol-Degrading Microorganisms in UASB Granular Sludge as Revealed by Fluorescence in situ Hybridization

Kengo Kubota, Kei Igarashi, Masayoshi Yamada, Yasuyuki Takemura, Yu-You Li, Hideki Harada

Journal Article

The Sustainable Exploitation of Marine Fish Resources and the Research Directions of Science and Technologyfor Marine Fish

Lin Haoran

Journal Article

Recent advances of small-molecule fluorescent probes for detecting biological hydrogen sulfide

Journal Article

Comments on “Determination of heterozygosity for avirulence/virulence loci through sexual hybridization

Ralf T. Voegele

Journal Article

Determination of heterozygosity for avirulence/virulence loci through sexual hybridization of

Yuan TIAN,Gangming ZHAN,Xia LU,Jie ZHAO,Lili HUANG,Zhensheng KANG

Journal Article

Short-term effects of excessive anaerobic reaction time on anaerobic metabolism of denitrifying polyphosphate- accumulating organisms linked to phosphorus removal and N

Gang GUO, Yayi WANG, Chong WANG, Hong WANG, Mianli PAN, Shaowei CHEN

Journal Article

Fluorescent properties and

Hong GAO,Jie SONG,Shibin SHANG,Zhanqian SONG

Journal Article

A novel flavonol-based colorimetric and turn-on fluorescent probe for rapid determination of hydrazine

Journal Article

Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging

Journal Article

Fluorescent probes and functional materials for biomedical applications

Journal Article

Effect of fiber hybridization on energy absorption and synergy in concrete

Ahmadreza RAMEZANI, Mohammad Reza ESFAHANI

Journal Article